Near the end of September, Dominic Purcell (DC's Legends of Tomorrow) revealed that there was going to be a sixth season for Prison Break. This wasn't confirmed by FOX, however. And that isn't going to happen anymore either. Wentworth Miller (The Flash (2014), who portrayed Michael J. Scofield, has revealed that he no longer wishes to portray the character. FOX has decided to cancel the series because of that decision.
Back in 2005, Prison Break premiered. After the fourth season released in 2009, the fans had to wait quite some time before the fifth season released. It took until 2017 before season five aired. Since then, speculation and hints about a sixth season were everywhere. Turns out, we won't be speculating anymore.