Mysteries at the Museum is een Amerikaanse serie van de zender Travel Channel. De serie ging in première in 2010.
Host Don Wildman introduceert ons aan een verschillende museums in de Verenigde Staten. Alleen gevuld met buitengewone en vaak bizarre objecten waar verbazingwekkende verhalen achter schuil gaan.
At the Municipal Archives in New York City is a black and white negative containing an image of a deadly weapon used in a sinister plot of revenge. Just uptown in New York's Times Square sits the world famous Madame Tussaud's Wax Museum, where the likeness of one revolutionary woman is on display. And on the grounds of the San Diego Air & Space Museum in California is a large missile that led to the creation of a product that's found in nearly every household in America.